Hi All ,
Recently i am facing this issue.  My EC2 instance are not getting into the internet access. Also, Instances are not communicating within  subnet and vpc
Here are details below.
Region: All the region
Security group inbound rules
Type      Protocol     Port Range          Source Description
HTTP     TCP              80                         0.0.0.0/0
HTTP     TCP               80                         ::/0
SSH        TCP              22                         0.0.0.0/0
HTTPS    TCP            443                        0.0.0.0/0
HTTPS   TCP            443                          ::/0
Security group outbound rules
Type                  Protocol   Port Range            Destination               Description
ALL Traffic         ALL           ALL                          0.0.0.0/0
ALL Traffic        ALL          ALL                             ::/0
NACL Inbound rules
Rule #                Type               Protocol             Port Range                Source                 Allow / Deny
100                     SSH (22)        TCP (6)                22                               0.0.0.0/0             ALLOW
101                    HTTP (80)      TCP (6)                80                               0.0.0.0/0              ALLOW
102                   HTTPS (443)  TCP (6)                443                             0.0.0.0/0              ALLOW
*                        ALL Traffic    ALL                   ALL                                  0.0.0.0/0               DENY
NACL outbound rules
Rule #                Type                               Protocol             Port Range                Destination           Allow / Deny
100                    ALL Traffic                    ALL                         ALL                               0.0.0.0/0                 ALLOW
101                   ALL Traffic                     ALL                          ALL                            ::/0                            ALLOW
*                        ALL  Traffic                    ALL                         ALL                               0.0.0.0/0                 DENY
Instance's Subnet associated route tables routes 
Destination            Target                                        Status              Propagated
10.10.0.0/16           local                                        Active                No
0.0.0.0/0               igw-099d16ab56df3a8e8      Active                 No
I have checked with different dhcp option sets, internet gateway and also with different AMIs.