I am considering the below data frame as an example to sort the data frame by columns. I want to sort the column 'd' in a descending manner and column 'b' in an ascending order. 
data <- data.frame(b = factor(c("Hey", "Medium", "Hey", "Low"), 
      levels = c("Low", "Medium", "Hey"), ordered = TRUE),
      x = c("W", "Z", "W", "Y"), y = c(7, 4, 8, 8),
      d = c(2, 2, 2, 3))
data
    b    x y d
1  Hey   W 7 2
2 Medium Z 4 2
3  Hey   W 8 2
4 Low    Y 8 3